You'll need to add the following lines to /etc/rc.d/rc.local: # Start vboxdrv if [ -x /etc/rc.d/rc.vboxdrv ]; then /etc/rc.d/rc.vboxdrv start fi This will load the support kernel module for VirtualBox. You'll then need to add the following lines to /etc/rc.d/rc.local_shutdown: # Stop vboxdrv if [ -x /etc/rc.d/rc.vboxdrv ]; then /etc/rc.d/rc.vboxdrv stop fi Any user accounts that plan to use virtualbox will need to be members of the "vboxusers" group.