At compile time, meme-suite checks if its database folder folder exists: /var/lib/meme-suite If you have installed any of the meme-db-* packages, this folder will be present. If you, however, want to install meme-suite first and later set the databases you need, just make sure that the folder is present before building meme-suite: mkdir -p /var/lib/meme-suite If you want to install the databases manually, they can be downloaded from here: http://meme-suite.org/doc/download.html